Choline Metabolism and Betaine Synthesis in Rat Brain
نویسندگان
چکیده
Introduction: Choline uptake and metabolism is decreased in older adults. A decrease in cholinergic function is characteristic of both normal aging and agerelated diseases (e.g., Alzheimer disease). Interestingly, the intensity of the signal at 3.2 ppm in lH-MRS (“choline” signal) serves as a marker for several brain pathologies including brain tumors. This chemical shift is indicative of the N-trimethylamine moiety shared by several water-soluble choline metabolites. The purpose of this study was two fold: 1. To search for specific differences in choline uptake and metabolism in the adult and the old rat brain. 2. To identify the water-soluble choline derivatives that may contribute to the “choline” signal in the brain. These goals were achieved by utilizing and [1,2-I%]-choline (1) and monitoring of choline metabolism in brain slices during perfusion and in extracts with 1%MRS.
منابع مشابه
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